The high prevalence of cardiovascular diseases demands a reliable and sensitive risk assessment technique. In order to develop a fast and label-free immunosensor for C-reactive protein, a risk factor for this condition, anti-CRP antibodies were physically adsorbed to the hydrogen -terminated surface of nanocrystalline diamond. An Enzyme-Linked ImmunoSorbent Assay reference technique showed that this was a suitable substrate for antibody-antigen recognition reactions. Electrochemical Impedance Spectroscopy was used to electronically detect CRP recognition. The specificity of the immunosensor was demonstrated by incubation (...) with CRP and plasminogen as reference molecule. A different impedance behavior was observed in real-time after CRP addition as compared to plasminogen addition: the impedance increased only during CRP incubation. Fitting the data showed that this corresponded with a decrease in capacitance of the molecular layer due to its increased thickness by specific CRP recognition. Sensitivity experiments in real-time showed a clear discrimination between 1 μM, 100 nM, and 10 nM of CRP after 10 min at 100 Hz. Since, 10 nM of CRP was still clearly distinguishable from buffer solution, our CRP-directed immunosensor prototype reaches a sensitivity that is within the physiologically relevant concentration range of this biomarker in healthy controls and CVD patients. Moreover, this prototype displayed real-time discriminating power between spiked and unspiked serum, and thus also shows its applicability in this biological matrix. © 2011 Elsevier B.V. All rights reserved. (shrink)

Diese fünfbändige Aristoteles-Ausgabe in griechischer Sprache ist (mit Ausnahme von Bd III) ein fotomechanischer Nachdruck der maßgeblichen Aristoteles-Ausgabe von 1831-1870. Band I und II enthält die Werke Aristoteles. In Band III wird die durch O. Gigon besorgte Bearbeitung und Ergänzung der Fragmente des Aristoteles wiedergegeben. Band IV bietet eine Auswahl der bedeutendsten Stücke aus den antiken Kommentaren zu Aristoteles, sowie eine Konkordanz mit den Commentaria in Aristotelem Graeca. In Band V ist der Index Aristotelicus von H. Bonitz nachgedruckt.

Studie se zabývá tím, jak se v českých zemích obráželo bouřlivé období vývoje biologického myšlení od přelomu 19. a 20. století do první světové války, kdy vedle sebe existovaly velmi různé názory na evoluci. Mnohovrstevnatost teoretickou přitom doplňuje i kulturní a vědecká mnohovrstevnatost českých zemí, kde se jednak mísí vlivy německé a české biologie na svých autonomních institucích, a jednak lze spatřovat rozdíly i mezi lokálními centry Prahou a Brnem se svými badatelskými tradicemi a nezávislými vazbami na další centra ve (...) Vídni a evropských univerzitách. Centrem zájmu jsou teoreticky uvažující biologové, kteří buď sami dlouhodobě profilovali české biologické myšlení, anebo na něj měli díky zdejšímu působení přímý vliv. V letech ca 1900–1915 došlo k prvnímu otevřenému a diskutovanému vrcholu v české recepci evolucionismu a před jednoznačnými pozicemi a „velkými teoriemi“ má navrch spíše prostředkování diferencované zahraniční diskuse, podněty vlastní experimentální práce a opatrné očekávání od nového studia variability a dědičnosti. (shrink)

1. Ursprünge und Entfaltungen.--II. Abenteuer der Seele.--v. 3. Wandel der Reiche.

This volume is a Festschrift dedicated to Charles Kahn comprised of more than 20 papers presented at the conference "Presocratics and Plato: Festschrift Symposium in Honor of Charles Kahn", 3-7 June 2009. The conference was held at the European Cultural Center of Delphi, Greece, and was organized and sponsored by the HYELE Institute for Comparative Studies and Parmenides Publishing, with endorsement from the International Plato Society, and the Dean of the School of Arts and Sciences, University of Pennsylvania. Contributors: Julia (...) Annas - University of Arizona; Sarah Broadie - University of St. Andrews; Lesley Brown - University of Oxford; Tomás Calvo-Martínez - Universidad Complutense de Madrid; Diskin Clay - Duke University; John M. Dillon - Trinity College, Dublin; Dorothea Frede - Humbolt University, Berlin; Arnold Hermann - HYELE Institute for Comparative Studies; Carl A. Huffman - DePauw University; Enrique Hülsz Piccone - Universidad Nacional Autonoma de Mexico; D.M. Hutchinson - St. Olaf College; Paul Kalligas - National and Kapodistrian University, Athens; Vassilis Karasmanis - National Technical University, Athens; Aryeh Kosman - Haverford College; Anthony A. Long - University of California, Berkeley; Richard McKirahan - Pomona College; Susan Sauvé Meyer - University of Pennsylvania; Alexander P.D. Mourelatos - University of Texas at Austin; Satoshi Ogihara - Tohoku University, Japan; Richard Patterson - Emory University; Christopher J. Rowe - Durham University; David Sedley - University of Cambridge; Richard Sorabji - University of Oxford. (shrink)

Bd. 1. Kants Theorie der Erfahrung (3 v.) -- Bd. 2. Kants Begründung der Ethik -- Bd. 3. Kants Begründung der Ästhetik -- Bd. 4. Kommentar zu Immanuel Kants Kritik der reinen Vernunft -- [Bd.] 5. Das Prinzip der Infinitesimal-Methode und seine Geschichte -- Bd. 6. System der Philosophie, 1. Teil -- Bd. 7. System der Philosophie, 2. Teil -- Bd. 8. System der Philosophie, 3. Teil, 1. Bd. -- Bd. 9. System der Philosophie, 3. Teil, 2. Bd. -- Bd. (...) 12. Kleinere Schriften I, 1865-1869 -- Bd. 15. Kleinere Schriften IV, 1907-1912. (shrink)

First ed. published in Jahrbuch feur Philosophie und Pheanomenologische Forschung, v. 11, 1930.

1 L’oggettivazione psicologistico-riduzonistico-introiettivistica Nella seconda metà del V secolo a. C. si ha in Grecia una radicale conversione del modo in cui l’uomo intende se stesso e il mondo nel quadro della cultura intellettuale europea che da quel momento sarà poi dominante: si tratta dell’oggettivazione psicologistico-riduzionistico-introiettivistica. Il mondo empirico viene smembrato in seguito alla separazione di un mondo interiore psichico ritenuto diverso per ogni possessore di c...

Guided by key insights of the four great philosophers mentioned in the title, here, in review of and expanding on our earlier work (Burchard, 2005, 2011), we present an exposition of the role played by language, & in the broader sense, λογοζ, the Logos, in how the CNS, the brain, is running the human being. Evolution by neural Darwinism has been forcing the linguistic nature of mind, enabling it to overcome & exploit the cognitive gap between an animal and its (...) world by recognizing environmental structures. Our work was greatly influenced by Heidegger’s lecture notes on metaphysics (Heidegger, 1935). We found agreement with recent progress in neuroscience, but also mathematical foundations of language theory, equating Logos with the mathematical concept of structure. The mystery of perception across the gap is analyzed as radiation and molecules impinging on sensory neurons that carry linguistic information about gross environmental structures, and only remotely about the physical reality of elementary particles. The most important logical brain function is Ego or Self, guiding the workings of the brain as a logos machine. Ego or Self operates from neurons in frontopolar cortex with global receptive fields. The logos machine can function only by availing itself of global context, its internally stored noumenal cosmos NK, and the categorical-conceptual apparatus CCA, updated continually through the neural default mode network (Raichle, 2005). In the Transcendental Deduction, Immanuel Kant discovered that Ego or Self is responsible for conscious control in perception relying on concepts & categories for a fitting percept to be incorporated intoNK. The entire CNS runs as a “movie-in-the-brain” (Parvizi & Damasio, 2001), at peak speed processing simultaneously in a series of cortical centers a stack of up to twelve frames in gamma rhythm of 25 ms intervals. We equate global context, or NK, with our human world, Heidegger’s Dasein being-in-the-world, and are able to demonstrate that the great philosopher in EM parallels neuro-science concerning the human mind. (shrink)

The philosophy of religion as presented by Hermann Cohen and Paul Natorp, the founders and main representatives of the Marburg School of Neo-Kantianism, is an important and at the same time controversial part of their philosophical systems. The discussion around the problems of religion began within the Marburg School and still continues among those who study that School. The reason for this is that “fitting” philosophical thinking about the phenomenon of religion into the classical triad of any system of (...) philosophy, i. e. effectively formulating that phenomenon in logical concepts, ethical postulates and aesthetic principles touched the very foundations of that system. Drawing mainly on the rough notes and correspondence of Cohen and Natorp I argue that, in spite of internal and quite important differences over the problems of religion and its place in philosophical constructions, Cohen and Natorp, first, retained their commitment to critical idealism and remained loyal to their philosophical school to the end and, second, followed the principle of mutual respect, preserving their professional and human sympathy for each other. Besides, I substantiate my assertion that Marburg Neo-Kantians had different concepts of the special place of religion in the system of philosophy. The specific nature of this difference warrants the discussion not only of the boundary of reason and rationality but adds new dimensions to that boundary, filling it with content and thus broadening the very sphere of critical idealism. In the course of the discussion of the problems of religion, Paul Natorp and Hermann Cohen stake a claim to projects for the serious transformation of philosophy which they tried to implement in their later works. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Discussions ARISTOTLE'S ALLEGED "REVOLT" AGAINST PLATO Hermippus' most conspicuous contribution to Aristotle's biography probably was his determined effort to depict Aristotle as the founder of an original school of philosophy which was wholly independent of Plato and Platonic teachings. Among the several and, in all likelihood, fanciful stories about Aristotle he invented or propagated, the most startling was the account, subsequently widely accepted (and widely exploited by (...) the detractors of Aristotle), that after having been a disciple of Plato for a while, he seceded from the Academy and from Plato's philosophic teachings while Plato was still alive. 1 Accordingly, he owed little to Plato and to the Academy. This story, invented and propagated by an inveterate Peripatetic (Hermippus), was intended to demonstrate the original philosophic genius of Aristotle which developed in complete independence of Plato and necessitated a break with the master's teachings. In devising his argument, Hermippus might have made use of a report, found in some of Aristotle's ancient biographers, that a few brash young men (members of the Academy?) revolted against Plato and, in a spirit of independence, defiance and antagonism, attempted to start a school of their own which would rival the intellectual standing of the Academy. 2 Hermippus, it appears, subsequently identified these young "rebels" with Aristotle, a substitution convenient to Hermippus" aim to depict Aristotle as a wholly independent and totally original philosopher who owed nothing whatever to Plato and his teachings. In all likelihood, Diogenes Laertius' statement that Aristotle "seceded from the Academy while Plato was still alive," a is just an echo either of a statement made by Hermippus himself or is a conclusion drawn from the several unpleasant stories about Aristotle invented and reported by some of Aristotle's detractors. According to these derogatory stories, there existed many serious personal as well as doctrinal 4 disagreements or rifts between Plato and the Stagirite--disagreeDiogenes Laertius, V. 2. See also Eusebius, Praeparatio Evangelica, XV. 2. 3, and ibid., XV. 2. 13 (Aristoxenus); Aelian, Varia Historia, IV. 9; Theodoretus, Graecorum Affectionum Curatio, IV. 46; St. Augustine, De Civitate Dei, VIII. 12; Philoponus, Comment. in Aristotelis Analytica Posteriora, CIAG, vol. XIII, part 3, pp. 133, 30 ft. 2 See Aelius Aristides, Oratio XLVI, 249. 10. See also note 1, supra. s Diogenes Laertius, V. 2. See also Vita Aristotelis Marciana 9; Vita Aristotelis Latina 9. 9 See, for instance, Plutarch, Adversus Coloten 14 (Moralia, III5A); Cicero, Academica I. 9. 33; Eusebius, op. cir., XV. 2, passim; Diogenes Laertius III. 37; Justin Martyr, Cohortatio ad Graecos 5 (Migne, PG. vol. VI. p. 247); Cyrillus, Contra Julianum II. 47; Proclus, [91] 92 HISTORY OF PHILOSOPHY ments whichmarred the relations between these two men and which were indicative of Aristotle's ingratitude, bad taste and unwarranted conceit. The report of Diogenes Laertius, in an oblique manner, may also refer to the fact that already during his active association with the Platonic Academy (367-348 B.c.), that is, in his On (the) Ideas and On the Good, Aristotle had begun to disagree with, and criticize, some of Plato's fundamental teachings. It may also, in a distorted form, refer to the following specific incident which, however, cannot be verified: According to Aristoxenus, during the absence of Plato in Syracuse (and while Heracleides of Pontus was the "acting scholarch" of the Academy),5 some unnamed young members of the Academy, or "students" or, perhaps, some "outsiders " attempted to start a rival school (within the Academy?).6 As a matter of fact, Aelian, who apparently dramatizes this incident, reports that during Plato's last years, that is, some time after Plato's return from his third and last voyage to Syracuse, a serious conflict or confrontation arose within the Academy. Aristotle, together with some of his friends, or "conspirators," we are told, harrassed and molested the aging Plato by constantly putting questions to him, by arguing with him in an insolent manner, by contradicting him on every point, and by attempting to involve him in hair-splitting dialectics. At the time Xenocrates was in Chalcedon, and Speusippus was gravely ill. Hence, neither of them could come to the succor of Plato. In... (shrink)

T. 1/2. Zugänge und Entwicklung (1 v.) -- T. 3. Metaspurenlesen tut not.

This book translates into English ten influential articles and extracts from books about Homer written in German over the past fifty years. The work of prestigious scholars such as Wolfgang Schadenwaldt, Karl Reinhardt, and Hermann Fraenkel are represented. These key works, which cover such topics as similes, the end of the Odyssey, the adventures of Odysseus, the meeting of Hector and Andromache, ring-composition, the Telemachy, and Homeric social life will now become easily accessible for the first time to teachers (...) and scholars in the English-speaking world. An accompanying introduction develops the arguments in the light of contemporary scholarly concerns. (shrink)

1. Die Hymnen des Rigveda, herausgegeben Oldenberg von Hermann. Band.I. Metrische und Textgeschichtliche Prolegomena. Berlin, 1888. 14 Mk.2. Vedische Studien, Pischel von Richard und Karl F. Geldner. Stuttgart, 1888–1889. 12 Mk.